Genetic link of oral cancer revealed

  • Research conducted by team of researchers of Department of Biochemistry in AIIMS

Chronicle Reporter, Bhopal
Oral cancer is the leading cause of cancer deaths in India. A study by a team of researchers from the Department of Biochemistry at AIIMS, Bhopal, throws light on the complex genetics behind oral cancer susceptibility.

The research was carried out by Dr. Shikha Tiwari under the guidance of Dr. Ashok Kumar, Additional Professor of Biochemistry at AIIMS Bhopal and in collaboration with Dr. Vinay Kumar, Department of Oncology, Dr. Vikas Gupta, Department of ENT and Dr. Saikat Das, Department of Radiotherapy .

The importance of this research echoed in front of Professor Ajay Singh, Executive Director and CEO of AIIMS Bhopal. The research team presented its findings to Professor Singh. who appreciated their efforts and provided invaluable guidance for future endeavours.

Pro. Singh stressed the need for multicenter studies and further exploration of the association with prognosis. This set the stage for an intense search for knowledge in the fight against oral cancer.

KASP technology used

This study reveals a significant association between specific genotypes and oral cancer susceptibility using competitive allele specific PCR (KASP technique). Individuals with the Scc genotype within the gene are more likely to develop oral cancer, as opposed to those with the CG or GG genotypes. Interestingly, it has the ability to inhibit its expression, as evidenced by elevated levels within oral cancer tumors compared with normal tissue.

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